Butyl bromide → HCID 15631955, compound

HRID 1368899Notes

Reaction equation

HRID 1368899 reaction equation
[O:1]1[C:5]2([CH2:10][CH2:9][NH:8][CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.Br[CH2:12][CH2:13][CH2:14][CH3:15].C(=O)([O-])[O-].[K+].[K+].[OH-].[Na+]>CN(C)C=O>[CH2:12]([N:8]1[CH2:9][CH2:10][C:5]2([O:4][CH2:3][CH2:2][O:1]2)[CH2:6][CH2:7]1)[CH2:13][CH2:14][CH3:15]

Participants

6

Reactant 4

HCID 8002Butyl bromideHCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 674351,4-Dioxa-8-azaspiro(4.5)decane

Product 1

HCID 15631955HCID 15631955, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 1,4-dioxa-8-azaspiro[4,5]decane (20.0 g, 140 mmol), 1-bromobutane (21,0 g, 154 mmol), potassium carbonate (19.3 g, 140 mmol) and dimethyl formamide (200 ml) was stirred for 5 h at 80° C. Sodium hydroxide (200 ml, 1 M) was added. The mixture was extracted three times with diethyl ether (200 ml). The product was isolated as an oil, in quantitative yield.

Workup

  1. extractionThe mixture was extracted three times with diethyl ether (200 ml)
  2. customThe product was isolated as an oil, in quantitative yield

Sources & evidence

ORD record
ord-47cb30da858949cab3c96de56c1f902f
Source dataset
uspto-grants-2003_06
Patent number
US06576641B2

Reaction notes

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