Benzyl chloroformate → HCID 20594533, compound

HRID 1370021Notes

Reaction equation

HRID 1370021 reaction equation
[NH2:1][C@@H:2]([CH2:7][CH2:8][CH3:9])[CH:3]1[NH:6][C:4]1=[O:5].C(=O)([O-])O.[Na+].[CH2:15]([O:22][C:23](Cl)=[O:24])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C1COCC1.O>[CH2:15]([O:22][C:23]([NH:1][C@@H:2]([CH2:7][CH2:8][CH3:9])[CH:3]1[NH:6][C:4]1=[O:5])=[O:24])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

6

Reactant 3

HCID 10387Benzyl chloroformateHCID 516892Sodium BicarbonateHCID 20594529HCID 20594529, compound

Product 1

HCID 20594533HCID 20594533, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution obtained by dissolving 3(S)-amino-2-caprolactam (5.00 g, 39.01 mmol) in THF (20 ml) and water (40 ml), sodium hydrogen carbonate (4.92 g, 58.56 mol) and benzyloxycarbonyl chloride (5.57 ml, 39.01 mmol) were added under ice cooling, and the mixture was stirred at room temperature for 18 hours.

Workup

  1. customTo a solution obtained
  2. additionwere added under ice cooling

Sources & evidence

ORD record
ord-e48a642dbaf949b093b47b366a95c097
Source dataset
uspto-grants-2003_06
Patent number
US06579989B1

Reaction notes

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