Sodium hydride → HCID 69959769, compound

HRID 1370773Notes

Reaction equation

HRID 1370773 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]=1[CH:13]=O.[H-].[Na+].[C:17]([CH2:19]P(=O)(OCC)OCC)#[N:18]>C1COCC1>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]=1[CH:13]=[CH:19][C:17]#[N:18]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 75676Diethyl (cyanomethyl)phosphonateHCID 793522-Methoxy-1-naphthaldehyde

Product 1

HCID 69959769HCID 69959769, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

Starting from 5 g (26.85 mmol) of 2-methoxynaphthaldehyde in 30 ml of anhydrous THF in the presence of 1.3 g (1.2 eq) of NaH (60% in oil) in 15 ml of anhydrous THF and 6.5 ml (1.2 eq) of diethyl cyanomethylphosphonate, the title product is obtained in the form of a white solid.

Sources & evidence

ORD record
ord-d8b9ef773b694a8d93e28a85ebdb6893
Source dataset
uspto-grants-2003_06
Patent number
US06583319B1

Reaction notes

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