Iodoethane → HCID 11974834, compound

HRID 1371640Notes

Reaction equation

HRID 1371640 reaction equation
I[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].[CH2:9](I)[CH3:10].C(=O)([O-])[O-].[K+].[K+].C([Li])CCC.CON(C)[C:26]([C:28]1[C:29]([NH2:37])=[N:30][C:31]([S:34][CH2:35][CH3:36])=[N:32][CH:33]=1)=[O:27]>CC(C)=O>[NH2:37][C:29]1[C:28]([C:26]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[O:8][CH2:9][CH3:10])=[O:27])=[CH:33][N:32]=[C:31]([S:34][CH2:35][CH3:36])[N:30]=1

Participants

7

Reactant 5

HCID 6340IodoethaneHCID 107842-IodophenolHCID 11430Potassium CarbonateHCID 119748325-Pyrimidinecarboxamide, 4-amino-2-(ethylthio)-N-methoxy-N-methyl-HCID 178418339Butyllithium

Product 1

HCID 11974834HCID 11974834, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The product of the reaction of 2-iodophenol (Aldrich) and ethyl iodide in hot acetone containing potassium carbonate was treated with n-butyl lithium as described in Example 2A and subsequently reacted with 4-amino-2-ethylsulfanyl-pyrimidine-5-carboxylic acid methoxy-methyl-amide, Example 1, using the procedure of Example 47 to give (4-amino-2-ethylsulfanyl-pyrimidin-5-yl)-(2-ethoxy-phenyl)-methanone as a white solid. MS (M+H)+, 304

Sources & evidence

ORD record
ord-4b11e9cae7c540cbb589b386e2557592
Source dataset
uspto-grants-2007_01
Patent number
US07157455B2

Reaction notes

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