Dimethylformamide → HCID 178434610, compound

HRID 1372006Notes

Reaction equation

HRID 1372006 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([C:7]([F:10])([F:9])[F:8])[NH:4][N:3]=1.CN(C=O)C.[Cl:16]N1C(=O)CCC1=O>O>[Cl:16][C:6]1[C:2]([CH3:1])=[N:3][NH:4][C:5]=1[C:7]([F:10])([F:9])[F:8]

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 31398ChlorosuccinimideHCID 1390771H-Pyrazole, 3-methyl-5-(trifluoromethyl)-

Product 1

HCID 178434610HCID 178434610, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
70 °C

Procedure

3-methyl-5-trifluoromethylpyrazole was taken into dry DMF (20 mL) and N-chloro succinimide (1.78 g) was added in portions. The mixture was then heated at 70° C. for 22 h, cooled to room temperature, and then water (100 mL) was added and the mixture extracted with ethyl acetate (4×25 mL). The organic layer was washed with water and brine and dried with Na2SO4. Evaporation of the solvent afforded the title compound.

Workup

  1. additionwas added in portions
  2. temperaturecooled to room temperature
  3. extractionthe mixture extracted with ethyl acetate (4×25 mL)
  4. washThe organic layer was washed with water and brine
  5. dry with materialdried with Na2SO4
  6. customEvaporation of the solvent

Sources & evidence

ORD record
ord-c19a261cb19544f488f88069e19c818b
Source dataset
uspto-grants-2007_01
Patent number
US07157464B2

Reaction notes

Loading…