Potassium Carbonate → HCID 12789607, compound

HRID 1373232Notes

Reaction equation

HRID 1373232 reaction equation
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[OH:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][C:19]([O:21][CH3:22])=[O:20])=[CH:14][CH:13]=1.C(=O)([O-])[O-].[K+].[K+]>C(OCC)(=O)C>[N+:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[O:11][C:12]1[CH:13]=[CH:14][C:15]([CH2:18][C:19]([O:21][CH3:22])=[O:20])=[CH:16][CH:17]=1)([O-:10])=[O:9]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 738951-Fluoro-2-nitrobenzeneHCID 518900Benzeneacetic acid, 4-hydroxy-, methyl ester

Product 1

HCID 12789607HCID 12789607, compoundYield 96.9%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
140 °C

Procedure

A mixture of 2-fluoronitrobenzene (1.1 g, 10 mmols), methyl p-hydroxyphenylacetate (1.7 g, 10 mmols) and potassium carbonate (1.4 g, 10 mmols) was stirred at 140° C. for 1 hour. The reaction mixture was diluted with ethyl acetate, then washed with water, and thereafter dried with anhydrous magnesium sulfate. This was concentrated under reduced pressure to give an oil of methyl 4-(2-nitrophenoxy)phenylacetate (2.78 g, 96.9%).

Workup

  1. washwashed with water
  2. dry with materialdried with anhydrous magnesium sulfate
  3. concentrationThis was concentrated under reduced pressure

Sources & evidence

ORD record
ord-eb0770fc6e1d4489ae89372be529db71
Source dataset
uspto-grants-2007_01
Patent number
US07160887B1

Reaction notes

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