Dimethyl malonate → HCID 16637924, compound

HRID 1374545Notes

Reaction equation

HRID 1374545 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH:10]([CH3:12])[CH3:11])=[CH:5][CH:4]=1.[CH3:13][O:14][C:15](=[O:21])[CH2:16][C:17]([O:19][CH3:20])=[O:18].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH3:13][O:14][C:15](=[O:21])[CH:16]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH:10]([CH3:12])[CH3:11])=[CH:5][CH:4]=1)[C:17]([O:19][CH3:20])=[O:18]

Participants

5

Reactant 3

HCID 7943Dimethyl malonateHCID 11430Potassium CarbonateHCID 12249109Benzene, 1-(chloromethyl)-4-(1-methylethoxy)-

Product 1

HCID 16637924HCID 16637924, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1-(Chloromethyl)-4-(1-methylethoxy)benzene (20.5 g, 111 mmol), malonic acid dimethyl ester (102.5 g, 776 mmol) and potassium carbonate (46.5 g, 332 mmol, anhydrous, freshly ground) are stirred in absolute DMF (250 ml) for 24 hours at 70° C.

Sources & evidence

ORD record
ord-348b4781162e47d9b7cc0228d2c279e0
Source dataset
uspto-grants-2007_01
Patent number
US07166588B2

Reaction notes

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