Methyl Acrylate → Methyl 4-acetyl-5-oxohexanoate

HRID 1375114Notes

Reaction equation

HRID 1375114 reaction equation
[C:1]([O:5][CH3:6])(=[O:4])[CH:2]=[CH2:3].[C:7]([CH2:10][C:11](=[O:13])[CH3:12])(=[O:9])[CH3:8].[Na]>>[CH3:6][O:5][C:1](=[O:4])[CH2:2][CH2:3][CH:10]([C:11](=[O:13])[CH3:12])[C:7](=[O:9])[CH3:8]

Participants

4

Reactant 3

HCID 7294Methyl AcrylateHCID 31261AcetylacetoneHCID 5360545Sodium

Product 1

HCID 281668Methyl 4-acetyl-5-oxohexanoate

Procedure

4-acetyl-5-oxohexanoic acid methyl ester was prepared through the Michael addition of methyl acrylate to acetyl acetone in the presence of metallic sodium. The crude product was purified by vacuum distillation and received in a purity of approximately 99%.

Workup

  1. distillationThe crude product was purified by vacuum distillation

Sources & evidence

ORD record
ord-8d22ed37bdee427c8a0568662258ebb2
Source dataset
uspto-grants-2007_01
Patent number
US07166648B2

Reaction notes

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