1-Tetralone → 3349-64-2

HRID 1375346Notes

Reaction equation

HRID 1375346 reaction equation
[CH2:1]1[CH2:11][C:9](=O)[C:8]2[C:3](=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:2]1.Cl.[NH2:13][OH:14].O.C(=O)([O-])[O-].[Na+].[Na+]>CO>[C:9]1(=[N:13]/[OH:14])\[CH2:11][CH2:1][CH2:2][C:3]2[C:8]\1=[CH:7][CH:6]=[CH:5][CH:4]=2

Participants

5

Reactant 3

HCID 107241-TetraloneHCID 443297Hydroxyamine hydrochlorideHCID 2735133Sodium Carbonate Monohydrate

Product 1

HCID 53551863349-64-2

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of α-tetralone (50 g, 45.5 mL, 342 mmol) in anhydrous methanol (500 mL) was added hydroxylamine hydrochloride (24.7 g, 377 mmol) and sodium carbonate monohydrate (45 g, 363 mmol). The resulting slurry was stirred at ambient temperature for 36 h and the solvent was removed. The residue was titurated with water and the resulting solid was recrystallized from ether/hexanes to supply the product (37.1 g) as greenish tan crystals.

Workup

  1. customthe solvent was removed
  2. customthe resulting solid was recrystallized from ether/hexanes to supply the product (37.1 g) as greenish tan crystals

Sources & evidence

ORD record
ord-faaf5a891bc94e55bd1cfd3e561ace8e
Source dataset
uspto-grants-2007_01
Patent number
US07169773B2

Reaction notes

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