反应详情

2.98 g (9.74 mmol) of 5(S)-[1(S)-(Boc-amino)-2-phenylethyl]-dihydrofuran-2-(3H)-one dissolved in 40 ml of THF are deprotonated at -75° C. with 19.5 ml of lithium bis(trimethylsilyl)amide 1M in THF and alkylated with 2.9 g (11.7 mmol) of p-methoxybenzyl iodide in 20 ml of THF (45 min). Column chromatography (SiO2, hexane/ethyl acetate 2:1) and digestion using diisopropyl ether yield the pure title compound; TLC Rf (D)=0.32; tRet (I)=16.7 min.