Hydrochloric Acid → HCID 178441670, compound

HRID 1377519Notes

Reaction equation

HRID 1377519 reaction equation
[CH2:1]([C:5]1[N:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[C:23]3[N:27](C(OCC)C)[N:26]=[N:25][N:24]=3)=[CH:13][CH:12]=2)[C:8]([C:33]([C:35]2[CH:40]=[CH:39][CH:38]=[C:37]([CH:41](OC)[O:42]C)[N:36]=2)=[O:34])=[C:7]([Cl:46])[N:6]=1)[CH2:2][CH2:3][CH3:4].Cl.[OH-].[Na+]>O1CCCC1>[CH2:1]([C:5]1[N:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[C:23]3[NH:27][N:26]=[N:25][N:24]=3)=[CH:13][CH:12]=2)[C:8]([C:33]([C:35]2[CH:40]=[CH:39][CH:38]=[C:37]([CH:41]=[O:42])[N:36]=2)=[O:34])=[C:7]([Cl:46])[N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22914886HCID 22914886, compound

Product 1

HCID 178441670HCID 178441670, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

186 mg (0.289 mmole) of the compound obtained in step 2 of Example 1 was dissolved in 3 ml of tetrahydrofuran and to the resulting solution was added 2 ml of aqueous 4N HCl solution. The resultant was stirred for 15 hours at room temperature, neutralized with aqueous 4N NaOH solution, concentrated under reduced pressure and purified with silica gel column chromatography to obtain 108 mg of the title compound (yield 71%).

Workup

  1. concentrationconcentrated under reduced pressure
  2. custompurified with silica gel column chromatography

Sources & evidence

ORD record
ord-cb1c9fbae3884c8e915203c2b72886f9
Source dataset
uspto-grants-1997_09
Patent number
US05665738

Reaction notes

Loading…