Hydrochloric Acid → HCID 178441666, 화합물

HRID 1377522노트

반응식

HRID 1377522 반응식
[CH2:1]([C:5]1[N:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[C:23]3[N:27](C(OCC)C)[N:26]=[N:25][N:24]=3)=[CH:13][CH:12]=2)[C:8]([C:33]([C:35]2[CH:40]=[CH:39][CH:38]=[C:37]([CH2:41][N:42]([CH2:45][CH3:46])[CH2:43][CH3:44])[N:36]=2)=[O:34])=[C:7]([Cl:47])[N:6]=1)[CH2:2][CH2:3][CH3:4].Cl.[OH-].[Na+]>O1CCCC1>[CH2:1]([C:5]1[N:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[C:23]3[NH:27][N:26]=[N:25][N:24]=3)=[CH:13][CH:12]=2)[C:8]([C:33]([C:35]2[CH:40]=[CH:39][CH:38]=[C:37]([CH2:41][N:42]([CH2:43][CH3:44])[CH2:45][CH3:46])[N:36]=2)=[O:34])=[C:7]([Cl:47])[N:6]=1)[CH2:2][CH2:3][CH3:4]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22914883HCID 22914883, 화합물

생성물 1

HCID 178441666HCID 178441666, 화합물수율 85.8%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

21 mg (0.032 mmole) of the compound obtained in step 1 was dissolved in 0.5 ml of tetrahydrofuran and to the resulting solution was added 0.3 ml of aqueous 1N HCl solution. The resultant was stirred for 5 hours at room temperature, neutralized with aqueous 1N NaOH solution, concentrated under reduced pressure and purified with silica gel column chromatography to obtain 16 mg of the title compound (yield 85.8%).

후처리

  1. concentrationconcentrated under reduced pressure
  2. custompurified with silica gel column chromatography

출처 및 근거

ORD 기록
ord-e9a07be3ae3446d8a6027ff2cfde74b7
출처 데이터셋
uspto-grants-1997_09
특허 번호
US05665738

반응 노트

불러오는 중…