4-Aminobenzoic Acid → HCID 178419805, compound

HRID 1377934Notes

Reaction equation

HRID 1377934 reaction equation
[C:1]12[CH:24]=[C:22]3[N:23]=[C:19]([CH:20]=[CH:21]3)[CH:18]=[C:16]3[NH:17][C:13]([CH:14]=[CH:15]3)=[CH:12][C:10]3=[N:11][C:7]([N:8]=[CH:9]3)=[N:6][C:4]([NH:5]1)=[N:3][N:2]=2.[CH:25]1[C:30]([C:31]([OH:33])=[O:32])=[CH:29][CH:28]=[C:27]([NH2:34])[CH:26]=1.NCCCC[C:40]1([OH:60])[C:53]2[O:54][C@@H:50]3[C@@:51]45[CH2:55][CH2:56][N:57]([CH3:58])[C@@H:45]([C@@H:46]4[CH:47]=[CH:48][C@@H:49]3[OH:59])[CH2:44][C:43]([C:52]5=2)=[CH:42][CH2:41]1.CCOC(OC(OCC)=O)=O>CN(C=O)C.C(N(CC)CC)C>[C:1]12[CH:24]=[C:22]3[N:23]=[C:19]([CH:20]=[CH:21]3)[CH:18]=[C:16]3[NH:17][C:13]([CH:14]=[CH:15]3)=[CH:12][C:10]3=[N:11][C:7]([N:8]=[CH:9]3)=[N:6][C:4]([NH:5]1)=[N:3][N:2]=2.[CH:25]1[C:30]([C:31]([OH:33])=[O:32])=[CH:29][CH:28]=[C:27]([NH2:34])[CH:26]=1.[CH:42]1[C:43]2[CH2:44][C@H:45]3[N:57]([CH2:56][CH2:55][C@@:51]45[C@H:46]3[CH:47]=[CH:48][C@H:49]([OH:59])[C@@H:50]4[O:54][C:53]([C:52]=25)=[C:40]([OH:60])[CH:41]=1)[CH3:58]

Participants

7

Reactant 4

HCID 9784-Aminobenzoic AcidHCID 3051Diethyl PyrocarbonateHCID 70137616HCID 70137616, compoundHCID 178419804HCID 178419804, compound

Product 1

HCID 178419805HCID 178419805, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8471TriethylamineSolvent

Procedure

A solution of each of the compounds obtained in Examples 31 to 39, i.e., tetraazaporphin (synthesized in Examples 1 to 9)-PABA and 3-(4-aminobutyl)morphine in DMF was treated with DEPC in the presence of triethyl amine in the same manner as described in Examples 31 to 39. Thus, tetraazaporphin-PABA-morphine combined products were obtained.

Sources & evidence

ORD record
ord-7828e8e4bd9a4020a44cb43ce8480a52
Source dataset
uspto-grants-1997_09
Patent number
US05665875

Reaction notes

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