tert-Butyl isocyanate → HCID 54046895, compound

HRID 1378377Notes

Reaction equation

[F:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.[Li+].CC([N-]C(C)C)C.FC1C=NC=CC=1[Li].[C:24]([N:28]=[C:29]=[O:30])([CH3:27])([CH3:26])[CH3:25]>>[C:24]([NH:28][C:29]([C:7]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[F:1])=[O:30])([CH3:27])([CH3:26])[CH3:25]

Participants

Reactant 4

HCID 62412tert-Butyl isocyanate

HCID 677943-Fluoropyridine

HCID 2724682Lithium diisopropylamide

HCID 178506753HCID 178506753, compound

Product 1

HCID 54046895HCID 54046895, compound

Procedure

Following the procedure of Gribble and Saulnier, Tetrahedron Lett., 21:4137-4140 (1980)) reacting 3-fluoropyridine (Aldrich) with LDA and reacting the 3-fluoro-4-lithiopyridine intermediate with t-butyl isocyanate, the title compound was prepared.

Sources & evidence

ORD record: ord-50c8f29eb80c4451a9815b50eaf4fff6
Source dataset: uspto-grants-1997_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05668141

Reaction notes

Loading…