Isopropanol → HCID 23324653, compound

HRID 1380832Notes

Reaction equation

Cl[C:2]1[N:7]=[C:6]([CH:8]([CH3:10])[CH3:9])[N:5]=[C:4]([CH2:11][Cl:12])[CH:3]=1.[Na].[CH:14]([OH:17])([CH3:16])[CH3:15]>>[Cl:12][CH2:11][C:4]1[CH:3]=[C:2]([O:17][CH:14]([CH3:16])[CH3:15])[N:7]=[C:6]([CH:8]([CH3:10])[CH3:9])[N:5]=1

Participants

Reactant 3

HCID 3776Isopropanol

HCID 5360545Sodium

HCID 23324650HCID 23324650, compound

Product 1

HCID 23324653HCID 23324653, compound

Procedure

6-Chloro-4-chloromethyl-2-isopropyl-pyrimidine (see Example 61) is reacted with isopropanol and sodium analogously to the process described in Example 62 in order to produce 4-chloromethyl-2-isopropyl-6-isopropoxy-pyrimidine which is required as the starting material in Example 22. This product is obtained in the form of an oil, 1H-NMR (CDCl3): 1.30 (d, 2×CH3), 1.37 (d, 2×CH3), 3.10 (m, CH), 4.50 (s, CH), 5.40 (m, CH), 6.65 (s, CH).

Sources & evidence

ORD record: ord-7672cbeaea1c42768de135e42eb1e753
Source dataset: uspto-grants-1986_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04584295

Reaction notes

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