Benzyl Bromide → HCID 13035738, compound

HRID 1381115Notes

Reaction equation

HRID 1381115 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][C:11]2[NH:10][C:9](=[O:14])[N:8]3[CH2:15][CH2:16][N:17]=[C:7]3[C:6]=2[CH:5]=1)([O-:3])=[O:2].[OH-].[Na+].[CH2:20](Br)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C(Cl)Cl>[N+:1]([C:4]1[CH:13]=[CH:12][C:11]2[N:10]([CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:9](=[O:14])[N:8]3[CH2:15][CH2:16][N:17]=[C:7]3[C:6]=2[CH:5]=1)([O-:3])=[O:2]

Participants

6

Reactant 3

HCID 7498Benzyl BromideHCID 14798Sodium HydroxideHCID 178517283HCID 178517283, compound

Product 1

HCID 13035738HCID 13035738, compound

Reagents, catalysts & solvents 2

HCID 74236Tetrabutylammonium BromideCatalystHCID 6344DichloromethaneSolvent

Procedure

11.5 g (0.05 mol) of 9-nitro-5-oxo-2,3,5,6-tetrahydroimidazo-[1,2-c]-quinazoline and 6.4 g (0.02 mol) of tetra-n-butylammonium bromide were suspended in 250 ml of 10% strength sodium hydroxide solution. 17.815 g (0.15 mol) of benzyl bromide in 150 ml of methylene chloride were added to the mixture, and the latter was stirred for 2 hours at room temperature.

Sources & evidence

ORD record
ord-c82b8b909f254f6f876a0592bff80882
Source dataset
uspto-grants-1986_04
Patent number
US04585772

Reaction notes

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