Dimethylformamide → HCID 19838231, compound

HRID 1381623Notes

Reaction equation

HRID 1381623 reaction equation
[C:1]1([CH2:7][O:8][C:9]2[CH:10]=[C:11]([CH2:23][CH2:24][NH:25][C:26](=[O:31])[C:27]([F:30])([F:29])[F:28])[CH:12]=[CH:13][C:14]=2[O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Na+].CN(C)[CH:36]=[O:37]>>[C:1]1([CH2:7][O:8][C:9]2[CH:10]=[C:11]([CH2:23][CH2:24][N:25]([CH2:11][CH2:10][CH2:9][CH2:14][CH2:13][CH2:12][O:37][CH2:36][CH2:7][C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[C:26](=[O:31])[C:27]([F:29])([F:30])[F:28])[CH:12]=[CH:13][C:14]=2[O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 6228Dimethylformamide2×HCID 24758Sodium hydrideHCID 19838104HCID 19838104, compound

Product 1

HCID 19838231HCID 19838231, compound

Conditions

Temperature
70 °C

Procedure

A solution of N-[2-[3,4-Bis(phenylmethoxy)phenyl]ethyl]-2,2,2-trifluoroacetamide (11 g) in dry dimethylformamide (30 ml) was added dropwise to a stirred suspension of sodium hydride (0.615 g) in dry dimethylformamide (20 ml) in (a) nitrogen atmosphere. The mixture was heated at 70° C. for 1 hour and then cooled to room temperature.

Workup

  1. temperaturecooled to room temperature

Sources & evidence

ORD record
ord-ced21b9873364c2b9edfbdaef9b4d254
Source dataset
uspto-grants-1989_02
Patent number
US04803225

Reaction notes

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