Hydrochloric Acid → HCID 21275487, compound

HRID 1381902Notes

Reaction equation

HRID 1381902 reaction equation
[CH3:1][O:2][C:3]1([O:16]C)[C:8](=O)[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[S:12][CH:13]=[CH:14][N:15]=2)[S:4]1.Cl.[Na]>>[CH3:10][C:6]1[N:7]=[C:8]([C:3]([O:2][CH3:1])=[O:16])[S:4][C:5]=1[C:11]1[S:12][CH:13]=[CH:14][N:15]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 5360545SodiumHCID 21275473HCID 21275473, compound

Product 1

HCID 21275487HCID 21275487, compoundYield 82.2%

Procedure

A mixture of 2,2-dimethoxy-5-methyl-6-(2-thiazolyl)-2H-1,4-thiazin-3-(4H)-one (80 mg) and 2N hydrochloric acid solution (2 ml) was stirred at room temperature for 6 hours. Then the mixture was neutralized with saturated sodium bicarbonated aqueous solution and the resulting precipitates were collected to give methyl 4-methyl-5-(2-thiazolyl)-thiazole-2-carboxylate (58 mg, yield 82.2%) as colorless powder.

Workup

  1. customthe resulting precipitates
  2. customwere collected

Sources & evidence

ORD record
ord-add21d9b0a42484bb671eb76c032a7e9
Source dataset
uspto-grants-1989_02
Patent number
US04804668

Reaction notes

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