Acetonitrile → HCID 14253456, compound

HRID 1381981Notes

Reaction equation

HRID 1381981 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][N:10]=1)[C:5](Cl)=[O:6].[CH3:11][NH:12][CH2:13][CH2:14][C:15]#[N:16].C(N(CC)CC)C.C(#N)C>C(OCC)(=O)C.O>[C:15]([CH2:14][CH2:13][N:12]([CH3:11])[C:5](=[O:6])[C:4]1[CH:8]=[CH:9][N:10]=[C:2]([Cl:1])[CH:3]=1)#[N:16]

Participants

7

Reactant 4

HCID 6342AcetonitrileHCID 8471TriethylamineHCID 69656Propanenitrile, 3-(methylamino)-HCID 28000032-Chloropyridine-4-carbonyl chloride

Product 1

HCID 14253456HCID 14253456, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8857Ethyl AcetateSolvent

Procedure

2 g (0.0136 mol) of 2-chloroisonicotinoyl chloride was added dropwise to a solution comprising 1.2 g (0.01136 mol) of N-methyl-N-(2-cyanoethyl)amine, 1.9 ml (0.0136 mol) of triethylamine and 30 ml of acetonitrile under cooling at 5° to 10° C. The mixture was stirred at room temperature for 2 h and then poured into water. Ethyl acetate was added thereto to conduct extraction.

Workup

  1. temperatureunder cooling at 5° to 10° C
  2. extractionextraction

Sources & evidence

ORD record
ord-34b8653632054d0796eef6eeabe4221b
Source dataset
uspto-grants-1989_02
Patent number
US04804762

Reaction notes

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