Sodium hydride → HCID 70377373, compound

HRID 1382643Notes

Reaction equation

HRID 1382643 reaction equation
[C:1]1(/[C:7](/[C:19]2[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=2)=[C:8](/[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)\[C:9]([F:12])([F:11])[F:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Na+].Cl[CH2:29][CH2:30][N:31]1[CH2:35][CH2:34][CH2:33][CH2:32]1>C1(C)C(C)=CC=CC=1>[C:1]1(/[C:7](/[C:19]2[CH:24]=[CH:23][C:22]([O:25][CH2:29][CH2:30][N:31]3[CH2:35][CH2:34][CH2:33][CH2:32]3)=[CH:21][CH:20]=2)=[C:8](/[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)\[C:9]([F:12])([F:11])[F:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 816691-(2-Chloroethyl)pyrrolidineHCID 7037736179258-51-8

Product 1

HCID 70377373HCID 70377373, compoundYield 61.4%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

2.72 g (8 mmoles) of (E)-1,2-diphenyl-3,3,3-trifluoro-1-(4-hydroxyphenyl)-propene, prepared as described in Example 26, are reacted in xylene with sodium hydride and then with 2-chloroethyl-pyrrolidine as described in Example 26. The product is crystallized from hexane. 2.15 g (61.4%) of the desired compound are obtained; m.p.: 84.5°-86° C.

Workup

  1. customThe product is crystallized from hexane

Sources & evidence

ORD record
ord-30fbab3365a44ad6983f37292a5db494
Source dataset
uspto-grants-1989_02
Patent number
US04806685

Reaction notes

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