反应详情

温度

62.5 °C

A solution of methyl 3-hydroxy-4-nitrobenzoate (5.9 g) in dimethylformamide (40 mL) is treated with potassium carbonate (6.2 g) and 2-bromopropane (3.7 g), and the stirred solution is heated at 60-65° C. for 4 hours. After cooling, water (100 mL) is added and the solution is extracted with toluene (2×100 mL). The combined organic extracts are dried over magnesium sulfate and evaporated in vacuo, to give methyl 3-isopropoxy-4-nitrobenzoate, in the form of a pale yellow solid (5.9 g), m.p. 46-48° C.

1. temperatureAfter cooling
2. extractionthe solution is extracted with toluene (2×100 mL)
3. dry with materialThe combined organic extracts are dried over magnesium sulfate
4. customevaporated in vacuo