反应详情

A solution of 3-iodophenyl-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthyl)methanone (10.5 g, 25.1 mmol), palladium diacetate (564 mg, 2.5 mmol) and tributylamine (12 ml, 50.5 mmol) in methanol (500 ml) is heated for 3 h at 100° C. under a pressure of carbon monoxide (3 bar). After concentration on an evaporator under vacuum at 40° C., the oil obtained is diluted in ethyl acetate and washed three times with water. The product is purified by flash chromatography on a column of silica.

1. concentrationAfter concentration
2. customon an evaporator under vacuum at 40° C.
3. customthe oil obtained
4. washwashed three times with water
5. customThe product is purified by flash chromatography on a column of silica