Hydrochloric Acid → HCID 70182737, compound

HRID 1384170Notes

Reaction equation

HRID 1384170 reaction equation
[CH3:1][C:2]1([CH3:29])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([C:14]([C:16]3[CH:17]=[C:18]([CH:22]=[CH:23][C:24]([O:26]CC)=[O:25])[CH:19]=[CH:20][CH:21]=3)=[CH2:15])[CH:5]=[CH:4][C:3]1=2.[OH-].[Na+].Cl>C1COCC1>[CH3:1][C:2]1([CH3:29])[CH2:11][CH2:10][C:9]([CH3:12])([CH3:13])[C:8]2[CH:7]=[C:6]([C:14]([C:16]3[CH:17]=[C:18]([CH:22]=[CH:23][C:24]([OH:26])=[O:25])[CH:19]=[CH:20][CH:21]=3)=[CH2:15])[CH:5]=[CH:4][C:3]1=2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 70183438HCID 70183438, compound

Product 1

HCID 70182737HCID 70182737, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of the product of Example 11 (690 mg, 1.8 mmol) and sodium hydroxide (285 mg) in THF (20 ml) is refluxed for 8 h, acidified to pH 1 (concentrated HCl), extracted with ethyl acetate and washed with water. After drying, the organic phase is concentrated on a rotary evaporator under vacuum at 40° C. and the product is washed with heptane.

Workup

  1. extractionextracted with ethyl acetate
  2. washwashed with water
  3. customAfter drying
  4. concentrationthe organic phase is concentrated on a rotary evaporator under vacuum at 40° C.
  5. washthe product is washed with heptane

Sources & evidence

ORD record
ord-01e946391f7f4ed881e25bb79e873dd9
Source dataset
uspto-grants-2001_07
Patent number
US06258775B1

Reaction notes

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