Dimethylformamide → (9-(3-Fluoro-5-(2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-5-yl)methanone

HRID 138452Notes

Reaction equation

HRID 138452 reaction equation
[CH3:23][CH2:24][N:25]([CH2:26][CH3:27])[CH2:28][CH3:29].[CH:30]([CH3:31])([CH3:32])[c:33]1[s:34][c:35]([C:38](=[O:39])[OH:40])[cH:36][n:37]1.[O:1]1[CH2:2][CH2:3][NH:4][CH2:5][C:6]12[CH2:7][CH2:8][N:9]([CH2:12][c:13]1[cH:14][c:15]([CH2:20][CH2:21][OH:22])[cH:16][c:17]([F:19])[cH:18]1)[CH2:10][CH2:11]2.[O:65]=[CH:66][N:67]([CH3:68])[CH3:69].[P-:41]([F:42])([F:43])([F:44])([F:45])([F:46])[F:47].[n:48]1([O:49][C:50]([N:51]([CH3:52])[CH3:53])=[N+:54]([CH3:55])[CH3:56])[c:57]2[n:58][cH:59][cH:60][cH:61][c:62]2[n:63][n:64]1>>[O:1]1[CH2:2][CH2:3][N:4]([C:38]([c:35]2[s:34][c:33]([CH:30]([CH3:31])[CH3:32])[n:37][cH:36]2)=[O:39])[CH2:5][C:6]12[CH2:7][CH2:8][N:9]([CH2:12][c:13]1[cH:14][c:15]([CH2:20][CH2:21][OH:22])[cH:16][c:17]([F:19])[cH:18]1)[CH2:10][CH2:11]2

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 9886HexafluorophosphateHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 197863422-(Propan-2-yl)-1,3-thiazole-5-carboxylic acidHCID 579889902-(3-(1-Oxa-4,9-diazaspiro[5.5]undecan-9-ylmethyl)-5-fluorophenyl)ethanol

Product 1

HCID 57988964(9-(3-Fluoro-5-(2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-5-yl)methanone

Sources & evidence

ORD record
ord-3c0c09d560434b449dc236eb20e171f3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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