反应详情

3.71 g of ethyl isonipecotate, 2.38 g of triethylamine and 10 ml of 2-propanol were added to 1 g of 2-chloro-4-(3,4-methylenedioxybenzyl) amino-6-cyanoquinazoline. The obtained mixture was refluxed for 1 hour and cooled to room temperature. The crystals thus precipitated were recovered by filtration and washed with water and ether successively to give 1.126 g of the title compound.

1. temperatureThe obtained mixture was refluxed for 1 hour
2. customThe crystals thus precipitated
3. filtrationwere recovered by filtration
4. washwashed with water and ether successively