Methanol → HCID 12723454, compound

Lit., J. Org. Chem., 53:5695 (1988). To a stirred solution of 0.70 g (3.1 mmol) palladium acetate, 16.9 g (156 mmol) benzoquinone and 0.4 ml (6.2 mmol) methanesulphonic acid in 200 ml methanol at room temperature was added via syringe pump over 4 h a solution of 5.95 ml (62 mmol) 1,3-cyclohexadiene in 5 ml methanol, and stirring continued for an additional 16 h. The reaction mixture was extracted three times with ether and the combined organic extracts washed successively with water, 2 M sodium hydroxide solution and saturated brine. The organic phases were dried over sodium sulphate and concentrated in vacuo. Kugelrohr distillation (6 mbar, oven temp 120° C.) afforded 5.42 g (61%) of the title compound as a colorless oil. 1H NMR d (250 MHz, CDCl3) 5.92 (2H, s), 3.70 (2H, t, J=5 Hz), 3.37 (6H, s), 1.90-1.65 (4H, m).

1. extractionThe reaction mixture was extracted three times with ether
2. washthe combined organic extracts washed successively with water, 2 M sodium hydroxide solution and saturated brine
3. dry with materialThe organic phases were dried over sodium sulphate
4. concentrationconcentrated in vacuo
5. distillationKugelrohr distillation (6 mbar, oven temp 120° C.)

ORD record

ord-5729320342e0416982a447c068079ccf

Source dataset

uspto-grants-2001_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06262089B1