反应详情

A stirred mixture of (0.7 g, 3.0 mmol) 8-amino-3-carboethoxy-2,6-dimethylimidazo[1,2-a]pyridine, (0.8 g, 3.5 mmol) 2-ethyl-4-fluoro-6-methylbenzylbromide, (0.7 g, 4.8 mmol) potassium carbonate and (0.1 g) sodium iodide in 15 ml acetonitrile was refluxed over night. After evaporation of the solvent under reduced pressure the residue was dissolved in dichloromethane and washed with water, the organic layer was separated dried over sodium sulfate and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel, eluent petroleum ether (40-60):isopropyl ether 7:3 to give 0.4 g, (35%) of the title compound.

1. temperaturewas refluxed over night
2. customAfter evaporation of the solvent under reduced pressure the residue
3. dissolutionwas dissolved in dichloromethane
4. washwashed with water
5. customthe organic layer was separated
6. dry with materialdried over sodium sulfate
7. customevaporated under reduced pressure
8. customThe residue was purified by column chromatography on silica gel, eluent petroleum ether (40-60)