Bromine → 5-Bromo-2-hydroxy-4-methyl-3-nitropyridine

HRID 1387272Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1387272
[CH3:1][C:2]1[CH:7]=[CH:6][NH:5][C:4](=[O:8])[C:3]=1[N+:9]([O-:11])=[O:10].C([O-])(=O)C.[Na+].[Br:17]Br>C(O)(=O)C.C(OCC)(=O)C>[Br:17][C:7]1[C:2]([CH3:1])=[C:3]([N+:9]([O-:11])=[O:10])[C:4](=[O:8])[NH:5][CH:6]=1

Komponenten

6

Edukt 3

HCID 24408BromineHCID 3453702-Hydroxy-4-methyl-3-nitropyridineHCID 517045Sodium Acetate

Produkt 1

HCID 217065175-Bromo-2-hydroxy-4-methyl-3-nitropyridineAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a stirred solution of 4-methyl-3-nitro-2-pyridone (0.45 g, 2.9 mmol) in glacial acetic acid (3 mL) was added sodium acetate (0.24 g) followed by bromine (0.15 mL) dropwise. After 5.5 hours, the mixture was diluted with ethyl acetate, washed with water, dried, filtered and concentrated to give 5-bromo-4-methyl-3-nitro-2-pyridone (0.62 g, 2.6 mmol, 90%).

Aufarbeitung

  1. washwashed with water
  2. customdried
  3. filtrationfiltered
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-ff99ebcc0a0c492eb6637ad3ceb0939a
Quelldatensatz
uspto-grants-2001_07
Patentnummer
US06268365B1

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