Dimethylformamide dimethyl acetal → HCID 18926908, compound

HRID 1387675Notes

Reaction equation

HRID 1387675 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:22](=[O:23])[C:13]3=[CH:14][NH:15][C:16]4[C:21]([N:12]3[C:11]2=[O:24])=[CH:20][CH:19]=[CH:18][CH:17]=4)=[CH:6][CH:5]=1)[CH3:2].[CH3:25]OC(OC)N(C)C>CN(C=O)C>[CH3:25][N:15]1[C:16]2[C:21](=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:12]2[C:11](=[O:24])[N:10]([C:7]3[CH:6]=[CH:5][C:4]([O:3][CH2:1][CH3:2])=[CH:9][CH:8]=3)[C:22](=[O:23])[C:13]2=[CH:14]1

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 178466709HCID 178466709, compound

Product 1

HCID 18926908HCID 18926908, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

2-(4-Ethoxyphenyl)-imidazo[1,5,a]quinoxaline-1,3(2H,5H)-dione (100 mg) was added to a solution of dimethylformamide dimethylacetal (10 ml,) and DMF (5 mL), and the reaction mixture was heated to 100° C. for 4 h. The solution was cooled to room temperature and poured onto water (200 mL). The resulting precipitate was collected and dried to yield 5-N-Methyl-2-(4-ethoxyphenyl)-imidazo[1,5,a]quinoxaline-1,3(2H,5H)-dione (Compound 42). m.p. 263-266° C.

Workup

  1. temperatureThe solution was cooled to room temperature
  2. additionpoured onto water (200 mL)
  3. customThe resulting precipitate was collected
  4. customdried

Sources & evidence

ORD record
ord-c60425e626da4b079ad36801c1a1ee56
Source dataset
uspto-grants-2001_07
Patent number
US06268496B1

Reaction notes

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