Methyl iodide → HCID 14292931, compound

Temperature

40 °C

Under argon 6.63 g of magnesium (273 mmol) was suspended in 15 mL of tert-butyl methyl ether. A solution of 38.68 g of methyl iodide (273 mmol) in 145 mL of tert-butyl methyl ether was added during 45 minutes under stirring while maintaining the temperature at 40° C. Then stirring was continued at 40° C. for 1.5 hours and then the mixture was cooled to room temperature. A solution of 30.0 g of methyl 4-benzyloxybenzoate (124 mmol) in 120 mL of tetrahydrofuran was then added during 1 hour. The temperature was kept at 20° C. After complete addition, the reaction mixture was heated to 42° C. and stirred 3 hours at this temperature. After cooling to room temperature, the reaction mixture was poured into a mixture of 300 mL of 10% aqueous ammonium chloride and 100 g of ice and extracted with ethyl acetate. The organic phases were washed with water and saturated aqueous sodium bicarbonate, combined, dried and evaporated to give the crude product as an oil which partially crystallised. The product was dissolved at 25° C. in diethyl ether. When crystals started to separate the solution was cooled to 18° C. After 30 minutes hexane was added. The suspension was then stirred for 1 hour at 5° C. The crystalline 2-(4-benzyloxy-phenyl)-propan-2-ol was collected on a filter and washed with hexane.

1. stirringThen stirring
2. temperaturethe mixture was cooled to room temperature
3. customwas kept at 20° C
4. additionAfter complete addition
5. temperaturethe reaction mixture was heated to 42° C.
6. stirringstirred 3 hours at this temperature
7. temperatureAfter cooling to room temperature
8. extractionextracted with ethyl acetate
9. washThe organic phases were washed with water and saturated aqueous sodium bicarbonate
10. customdried
11. customevaporated

ORD record

ord-6f8e6fde76af456782f5c4554d0de2da

Source dataset

uspto-grants-2001_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06268499B1