Tetrahydrofuran → HCID 53827115, compound

HRID 1389427Notes

Reaction equation

HRID 1389427 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([C:12]([N+:15]([O-])=O)=NO)[CH2:9][N:8]=[C:7]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[F:24])C=2C=1.[NH:26]1[CH2:30]CCC1.O1C[CH2:34][CH2:33][CH2:32]1.[CH2:36](O)[CH3:37].[O:39]1CCCC1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([CH:12]3[CH2:34][CH2:33][CH2:32][N:15]3[CH:30]=[N:26][OH:39])[CH2:9][N:8]=[C:7]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[F:24])[C:37]=2[CH:36]=1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 31268PyrrolidineHCID 21873804Tetrahydrofuran ethanolHCID 136335629HCID 136335629, compound

Product 1

HCID 53827115HCID 53827115, compound

Procedure

Reaction of 7-chloro-5-(2-fluorophenyl)-N-hydroxy-α-nitro-3H-1,4-benzodiazepine-2-methanimine with pyrrolidine in tetrahydrofuran overnight at room temperature yielded yellowish crystals. For analysis a sample was recyrstallized from tetrahydrofuran/ethanol, mp 175°-178° C.

Workup

  1. customyielded yellowish crystals

Sources & evidence

ORD record
ord-8d96408e37434a078099d68ee726209d
Source dataset
uspto-grants-1981_01
Patent number
US04244868

Reaction notes

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