反应详情

To a solution containing 5.4 g. (0.02 mole) of the sodium salt of 5-amino-7,8-dihydro-2-methyl-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester in 50 ml. of dimethylformamide was added 9.35 g. (0.06 mole) of ethyl iodide. The reaction mixture was heated to 50° for 4 hours; cooled in ice and then poured into one liter of water. The reaction mixture was kept in a cold room for 3 days and was then filtered. The product amounted to 3.4 g. (m.p. 230°-231°). The analytical sample was obtained by recrystallization from ethanol.

1. additionTo a solution containing 5.4 g
2. temperatureThe reaction mixture was heated to 50° for 4 hours
3. temperaturecooled in ice
4. filtrationwas then filtered
5. customThe analytical sample was obtained by recrystallization from ethanol