Dimethylformamide → HCID 53869479, compound

HRID 1389542Notes

Reaction equation

HRID 1389542 reaction equation
[Na].[CH2:2]([O:4][C:5]([C:7]1[C:17](=[O:18])[NH:16][C:10]2[N:11]=[C:12]([CH3:15])[N:13]=[CH:14][C:9]=2[C:8]=1[NH2:19])=[O:6])[CH3:3].CN(C)C=O.[CH2:25](I)[CH3:26]>O>[CH2:2]([O:4][C:5]([C:7]1[C:17](=[O:18])[N:16]([CH2:25][CH3:26])[C:10]2[N:11]=[C:12]([CH3:15])[N:13]=[CH:14][C:9]=2[C:8]=1[NH2:19])=[O:6])[CH3:3]

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 6340IodoethaneHCID 5360545SodiumHCID 541716925-Amino-7,8-dihydro-2-methyl-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

Product 1

HCID 53869479HCID 53869479, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution containing 5.4 g. (0.02 mole) of the sodium salt of 5-amino-7,8-dihydro-2-methyl-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester in 50 ml. of dimethylformamide was added 9.35 g. (0.06 mole) of ethyl iodide. The reaction mixture was heated to 50° for 4 hours; cooled in ice and then poured into one liter of water. The reaction mixture was kept in a cold room for 3 days and was then filtered. The product amounted to 3.4 g. (m.p. 230°-231°). The analytical sample was obtained by recrystallization from ethanol.

Workup

  1. additionTo a solution containing 5.4 g
  2. temperatureThe reaction mixture was heated to 50° for 4 hours
  3. temperaturecooled in ice
  4. filtrationwas then filtered
  5. customThe analytical sample was obtained by recrystallization from ethanol

Sources & evidence

ORD record
ord-63cab0ae29a3442daf56cf8ecb66e994
Source dataset
uspto-grants-1981_01
Patent number
US04245094

Reaction notes

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