Methanol → HCID 178522648, compound

HRID 1390012Notes

Reaction equation

HRID 1390012 reaction equation
[O:1]=[C:2]1[C:11]2[CH:10]=[CH:9][CH:8]=[C:7]([CH:12]3[CH2:16][CH2:15][CH2:14][S:13]3)[C:6]=2[NH:5][C:4]2=[CH:17][C:18]([C:20](O)=[O:21])=[N:19][N:3]12.CO.C(N1C=CN=C1)(N1C=CN=C1)=O.O.[NH2:38][C:39]1[NH:43][N:42]=[N:41][N:40]=1>CN(C=O)C>[O:1]=[C:2]1[C:11]2[CH:10]=[CH:9][CH:8]=[C:7]([CH:12]3[CH2:16][CH2:15][CH2:14][S:13]3)[C:6]=2[NH:5][C:4]2=[CH:17][C:18]([C:20]([NH:38][C:39]3[NH:43][N:42]=[N:41][N:40]=3)=[O:21])=[N:19][N:3]12

Participants

6

Reactant 4

HCID 887MethanolHCID 682631,1'-CarbonyldiimidazoleHCID 178509300HCID 178509300, compoundHCID 178524061HCID 178524061, compound

Product 1

HCID 178522648HCID 178522648, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

From 4,9-dihydro-9-oxo-5-(tetrahydro-2-thienyl)pyrazolo[5,1-b]quinazoline-2-carboxylic acid, compound with methanol (1:1) (0.40 g; 1.3 mmole), DMF (20 ml); 1,1' carbonyl-diimidazole (0.5 g; 3.1 mmole) and 5-amino-1H-tetrazole, monohydrate (0.131 g; 1.3 mmole), following the procedure of Example 3, there is obtained 4,9-dihydro-9-oxo-5-(tetrahydro-2-thienyl)-N-1H-tetrazol-5-yl-pyrazolo[5,1-b]quinazoline-2-carboxamide (70 mg); mp>230° (d).

Sources & evidence

ORD record
ord-b393faec401340f487e3a19106d1a494
Source dataset
uspto-grants-1981_01
Patent number
US04247555

Reaction notes

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