Hydrochloric Acid → HCID 21333180, compound

HRID 1390618Notes

Reaction equation

HRID 1390618 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH:5]=[C:6]([Cl:9])[C:7]=1[Cl:8].C(=O)([O-])[O-].[K+].[K+].[CH2:22](I)[CH3:23].Cl>CC(C)=O.CCOCC>[ClH:1].[Cl:9][C:6]1[CH:5]=[C:4]([N:10]2[CH2:11][CH2:12][N:13]([CH2:22][CH3:23])[CH2:14][CH2:15]2)[CH:3]=[C:2]([Cl:1])[C:7]=1[Cl:8]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 21333175HCID 21333175, compound

Product 1

HCID 21333180HCID 21333180, compoundYield 128.7%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 3283Diethyl EtherSolvent

Procedure

To a stirred mixture of 1-(3,4,5-trichlorophenyl)piperazine (0.5g) and anhydrous potassium carbonate (0.26 g) in dry acetone (5 ml) was added, slowly, ethyl iodide (0.29g) and the resulting mixture was stirred under reflux for 2 hr. then filtered. Removal of the solvent gave a pale brown solid which was dissolved in ether and treated with ethereal hydrogen chloride to give 1-(3,4,5-trichlorophenyl)-4-ethylpiperazine hydrochloride (0.4g, 67%), m.p. 265°-270° (from ethanol-ether).

Workup

  1. additionwas added
  2. temperatureunder reflux for 2 hr
  3. filtrationthen filtered
  4. customRemoval of the solvent
  5. customgave a pale brown solid which

Sources & evidence

ORD record
ord-ea4b9b81ee5d41f0b4fa9ee5312ad06b
Source dataset
uspto-grants-1979_02
Patent number
US04139621

Reaction notes

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