4-Nitrobenzyl chloride → 1-(4-nitrobenzyl)-4-phenylpiperazine

HRID 1391008Notes

Reaction equation

HRID 1391008 reaction equation
[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8]Cl)=[CH:6][CH:5]=1)([O-:3])=[O:2].Cl.Cl.[C:14]1([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(N(CC)CC)C>[C:14]1([N:20]2[CH2:25][CH2:24][N:23]([CH2:8][C:7]3[CH:10]=[CH:11][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=3)[CH2:22][CH2:21]2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 74824-Nitrobenzyl chlorideHCID 776191-Phenylpiperazine dihydrochloride

Product 1

HCID 2594881-(4-nitrobenzyl)-4-phenylpiperazine

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

In the manner given in Example 1A, p-nitrobenzyl chloride is reacted with phenylpiperazine dihydrochloride in the presence of triethylamine to give 1-phenyl-4-(p-nitrobenzyl)piperazine

Sources & evidence

ORD record
ord-a2efd700b2ad477d9fa8779e59668f4b
Source dataset
uspto-grants-1979_02
Patent number
US04140775

Reaction notes

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