Tert-Butylamine → HCID 178449860, compound

HRID 1393049Notes

Reaction equation

HRID 1393049 reaction equation
[CH3:1][C:2]1[CH:3]=[N:4][C:5]([CH2:11][S+:12]([O-:24])[C:13]2[NH:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH3:23])=[CH:19][C:20]=3[N:21]=2)=[C:6]([CH3:10])[C:7]=1[O:8][CH3:9].[C:25]([NH2:29])([CH3:28])([CH3:27])[CH3:26]>COC(C)(C)C>[C:25]([NH3+:29])([CH3:28])([CH3:27])[CH3:26].[CH3:23][O:22][C:18]1[CH:17]=[CH:16][C:15]2[NH:14][C:13]([S:12]([CH2:11][C:5]3[C:6]([CH3:10])=[C:7]([O:8][CH3:9])[C:2]([CH3:1])=[CH:3][N:4]=3)=[O:24])=[N:21][C:20]=2[CH:19]=1

Participants

4

Reactant 2

HCID 6385Tert-ButylamineHCID 178488147HCID 178488147, compound

Product 1

HCID 178449860HCID 178449860, compound

Reagents, catalysts & solvents 1

HCID 15413tert-Butyl methyl etherSolvent

Procedure

Omeprazole (1.0 g, 2.9 mmol) was dissolved in tert-butyl methyl ether (10 ml) at 60-70° C. Tert-butylamine (0.60 g, 8.1 mmol) was added and the mixture was then cooled to room temperature whereupon the product crystallised. The formed precipitate was filtered off and washed with in tert-butyl methyl ether. The title compound was obtained as a white solid.

Workup

  1. customcrystallised
  2. filtrationThe formed precipitate was filtered off
  3. washwashed with in tert-butyl methyl ether

Sources & evidence

ORD record
ord-91ed06affda04849935c93e4a82602b2
Source dataset
uspto-grants-2008_03
Patent number
US07345061B2

Reaction notes

Loading…