Sulfuric Acid → HCID 58018321, compound

HRID 1393070Notes

Reaction equation

HRID 1393070 reaction equation
[CH:1]([OH:4])([CH3:3])[CH3:2].S(=O)(=O)(O)O.[N+:10]([C:13]1[CH:34]=[CH:33][C:16]([CH2:17][C@@H:18]([C:30](O)=[O:31])[NH:19][C:20](=[O:29])[C:21]2[C:26]([Cl:27])=[CH:25][CH:24]=[CH:23][C:22]=2[Cl:28])=[CH:15][CH:14]=1)([O-:12])=[O:11]>O1CCCC1>[CH:1]([O:4][C:30](=[O:31])[C@H:18]([CH2:17][C:16]1[CH:15]=[CH:14][C:13]([N+:10]([O-:12])=[O:11])=[CH:34][CH:33]=1)[NH:19][C:20](=[O:29])[C:21]1[C:26]([Cl:27])=[CH:25][CH:24]=[CH:23][C:22]=1[Cl:28])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 3776IsopropanolHCID 58018322N-(2,6-Dichlorobenzoyl)-4-nitro-L-phenylalanine

Product 1

HCID 58018321HCID 58018321, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
50 °C

Procedure

Isopropanol (130 mL), tetrahydrofuran (50 mL) and sulfuric acid (0.44 mL) were added to 4-nitro-N-(2,6-dichlorobenzoyl)-L-phenylalanine (2.95 g, 7.70 mmol) and stirred at 50° C. for 5 days. After removing the solvent under reduced pressure, the obtained solid material was washed with water and dried to obtain 3.28 g of a white solid material.

Workup

  1. customAfter removing the solvent under reduced pressure
  2. washthe obtained solid material was washed with water
  3. customdried

Sources & evidence

ORD record
ord-7f0384011cc04bccb8a0f3eda6d020dd
Source dataset
uspto-grants-2008_03
Patent number
US07345049B2

Reaction notes

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