Benzyl Bromide → Benzyl 2-hydroxy-4-methylpentanoate

HRID 1393880Notes

Reaction equation

HRID 1393880 reaction equation
[OH:1][CH:2]([CH2:6][CH:7]([CH3:9])[CH3:8])[C:3]([OH:5])=[O:4].[CH2:10](Br)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C(N(CC)CC)C>C(OCC)(=O)C>[OH:1][CH:2]([CH2:6][CH:7]([CH3:9])[CH3:8])[C:3]([O:5][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:4]

Participants

5

Reactant 3

HCID 7498Benzyl BromideHCID 8471TriethylamineHCID 92779(+-)-2-Hydroxyisocaproic acid

Product 1

HCID 13908924Benzyl 2-hydroxy-4-methylpentanoate

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2-Hydroxy-4-methylpentanoic acid is reacted with benzyl bromide in ethyl acetate in the presence of triethylamine, to give benzyl 2-hydroxy-4-methylpentanoate.

Sources & evidence

ORD record
ord-eda15fcf322641b2a40c367dc9ad86cc
Source dataset
uspto-grants-2008_03
Patent number
US07348017B2

Reaction notes

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