Oxalyl chloride → HCID 17981884, compound

HRID 1394412Notes

Reaction equation

HRID 1394412 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][C:17]([OH:19])=O)=[CH:11][CH:10]=2)=[CH:4][CH:3]=1.C(Cl)(=O)C([Cl:23])=O>C(Cl)Cl.CN(C=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][C:17]([Cl:23])=[O:19])=[CH:11][CH:10]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 17981886HCID 17981886, compound

Product 1

HCID 17981884HCID 17981884, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

To a solution of acid from step 4 in CH2Cl2 (0.2M) was added oxalyl chloride (1.2 eq) and one drop of DMF. The mixture was stirred at rt for 3 h and the solvent evaporated. The crude acid chloride was used as such in the next step.

Workup

  1. customthe solvent evaporated

Sources & evidence

ORD record
ord-0654e37ea4f84859a51ca05c4242cdc5
Source dataset
uspto-grants-2008_03
Patent number
US07348433B2

Reaction notes

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