1-(2-Methoxyphenyl)piperazine → HCID 20340748, compound

HRID 1395262Notes

Reaction equation

HRID 1395262 reaction equation
Cl[CH2:2][CH2:3][CH2:4][C:5]1[N:13]=[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][N:7]2[N:6]=1.[CH3:14][O:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:14][O:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[N:22]1[CH2:27][CH2:26][N:25]([CH2:2][CH2:3][CH2:4][C:5]2[N:13]=[C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][N:7]3[N:6]=2)[CH2:24][CH2:23]1

Participants

5

Reactant 3

HCID 13461-(2-Methoxyphenyl)piperazineHCID 11430Potassium CarbonateHCID 20340740HCID 20340740, compound

Product 1

HCID 20340748HCID 20340748, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 3.9 g of 2-(3-chloropropyl)-s-triazolo[1,5-a]pyridine, 3.8 g of 1-o-methoxyphenylpiperazine and 2.8 g of potassium carbonate in 150 ml of dimethylformamide was refluxed for 8 hours. Then the reaction mixture was proceeded by the same manner as described in Example 2. The compound was recrystallized from cyclohexane to give colorless prisms, mp 55°-55.5° C. Yield was 60%. Anal. Calcd. for C20H25ON5 : C, 68.35; H, 7.17; N, 19.53. Found: C, 68.20; H, 6.94; N, 20.21.

Workup

  1. customThe compound was recrystallized from cyclohexane
  2. customto give colorless prisms, mp 55°-55.5° C

Sources & evidence

ORD record
ord-a865f5529d5c463fb5f262174bd653be
Source dataset
uspto-grants-1980_05
Patent number
US04202977

Reaction notes

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