Hydrochloric Acid → HCID 20574340, compound

HRID 1395670Notes

Reaction equation

HRID 1395670 reaction equation
C(N1CC(C2C=CC=CC=2)=C(O)C1=O)C=C.CN(C)CCCl.Cl.Cl.[CH2:25]([N:28]1[CH2:32][C:31]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)=[C:30]([O:39][CH2:40][CH2:41][N:42]([CH3:44])[CH3:43])[C:29]1=[O:45])[CH:26]=[CH2:27]>C(OCC)(=O)C>[CH2:25]([N:28]1[CH2:32][C:31]([C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)=[C:30]([O:39][CH2:40][CH2:41][N:42]([CH3:43])[CH3:44])[C:29]1=[O:45])[CH:26]=[CH2:27]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 79012-Chloro-N,N-dimethylethylamineHCID 20574342HCID 20574342, compoundHCID 20574349HCID 20574349, compound

Product 1

HCID 20574340HCID 20574340, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

In a manner analogous to that described in Example 1, 30.6 g. 1-allyl-3-hydroxy-4-phenyl-3-pyrrolin-2-one are reacted with 23.0 g. β-dimethylaminoethyl chloride. The base obtained is reacted with gaseous hydrogen chloride in ethyl acetate. There is obtained 15.0 g. (45.5% of theory) 1-allyl-3-(β-dimethylaminoethoxy)-4-phenyl-3-pyrrolin-2-one hydrochloride; m.p. 115°-117° C., after recrystallization from methyl ethyl ketone.

Workup

  1. customThe base obtained
  2. customThere is obtained 15.0 g
  3. customm.p. 115°-117° C., after recrystallization from methyl ethyl ketone

Sources & evidence

ORD record
ord-4ebe428a9af74464b1b37fa330bc2310
Source dataset
uspto-grants-1980_05
Patent number
US04205078

Reaction notes

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