Water → HCID 125482867, compound

HRID 1399399Notes

Reaction equation

HRID 1399399 reaction equation
[CH3:1][Si:2]([C:5]#[CH:6])([CH3:4])[CH3:3].[C:7]1([N:13]=[N+:14]=[N-:15])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.O[C@H:17]([C@@H]1C([O-])=C(O)C(=O)O1)CO.[Na+].O>S([O-])([O-])(=O)=O.[Cu+2].C(O)CCC>[C:7]1([N:13]2[CH:17]=[C:6]([CH2:5][Si:2]([CH3:4])([CH3:3])[CH3:1])[N:15]=[N:14]2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

7

Reactant 4

HCID 962WaterHCID 66111TrimethylsilylacetyleneHCID 69319AzidobenzeneHCID 23667548Sodium Ascorbate

Product 1

HCID 125482867HCID 125482867, compound

Reagents, catalysts & solvents 2

HCID 24462Copper SulfateCatalystHCID 2631-ButanolSolvent

Procedure

Trimethylsilylacetylene, phenylazide, copper (II) sulfate and sodium (R)-2-((S)-1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate were added to a 1:2 solution of water:butan-1-ol. The reaction was stirred for 4 days and t-butanol and water were removed, producing a 1-phenyl-4-((trimethylsilyl)methyl)-1H-1,2,3-triazole solid.

Workup

  1. customt-butanol and water were removed

Sources & evidence

ORD record
ord-6c039788de064fb183691a701ddff963
Source dataset
uspto-grants-2014_12
Patent number
US08906135B1

Reaction notes

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