Hydrochloric Acid → HCID 70987990, compound

HRID 1399499Notes

Reaction equation

HRID 1399499 reaction equation
C([NH:8][CH2:9][CH2:10][N:11]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([NH:20][CH2:21][CH2:22][S:23][C:24]([C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:19])[CH3:12])(OC(C)(C)C)=O.Cl>C1COCC1.O1CCOCC1>[NH2:8][CH2:9][CH2:10][N:11]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([NH:20][CH2:21][CH2:22][S:23][C:24]([C:37]1[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=1)([C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)[C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1)=[O:19])[CH3:12]

Participants

5

Reactant 2

HCID 313Hydrochloric Acid2×HCID 131732132HCID 131732132, compound

Product 1

HCID 70987990HCID 70987990, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 312751,4-DioxaneSolvent2×

Procedure

Boc-NH—(CH2)2—N(CH3)—(CH2)5—CONH—(CH2)2-STrt (62.8 mg, 0.11 mmol) was dissolved in THF (6 ml) and HCl in dioxane (130 μl, 4 M solution) was added. The reaction mixture was stirred for 12 h at RT. 200 μl HCl in dioxane was added and the solvent was removed in vacuo. The residue was purified by RP-HPLC to give H2N—(CH2)2—N(CH3)—(CH2)5—CONH—(CH2)2-STrt and not consumed starting material Boc-NH—(CH2)2—N(CH3)—(CH2)5—CONH—(CH2)2-STrt.

Workup

  1. customthe solvent was removed in vacuo
  2. customThe residue was purified by RP-HPLC

Sources & evidence

ORD record
ord-4ecbe608e180423db495c18309481637
Source dataset
uspto-grants-2014_12
Patent number
US08906847B2

Reaction notes

Loading…