4-Hydroxybenzoic Acid → Benzoic acid, 4-((1-oxodecyl)oxy)-

Temperature

15 °C

138.1 g (1 mol) of para-hydroxybenzoic acid were first dissolved in 400 ml of water and 600 ml of isopropanol and this solution was admixed at 0 to 5° C. with 235.7 g of KOH solution (50% strength by weight aqueous solution, 2.1 mol). The resulting pH was 14. Metered into this solution over the course of 15 minutes, then, at 5 to 25° C., without counter-cooling, were 190.7 g (1 mol) of decanoyl chloride, and the batch was stirred for 15 minutes thereafter. At the end of the after-stirring, the pH of the reaction mixture was 9.7. The reaction mixture was subsequently admixed at 25° C. with 25 g of HCl solution (32% strength by weight aqueous solution), and the complete solution was heated to 55 to 60° C. and then adjusted to a pH of 1.5 to 3 using 100 g of HCl solution (32% strength by weight aqueous solution). The reaction mixture was cooled to 20 to 25° C. and the solid was filtered off on a suction filter and washed ten times with 150 ml of water. The yield after drying under reduced pressure at 100° C. was 252.8 g (86.5% of theory). According to HPLC and NMR measurement, the product was free from decanoic acid and from unreacted para-hydroxybenzoic acid. The purity of the product is >99.9% by weight.

1. temperaturethe complete solution was heated to 55 to 60° C.
2. temperatureThe reaction mixture was cooled to 20 to 25° C.
3. filtrationthe solid was filtered off on a suction
4. filtrationfilter
5. washwashed ten times with 150 ml of water
6. customThe yield
7. customafter drying under reduced pressure at 100° C.

ORD record

ord-d01634a1ea174c9b82e3d076fab1c436

Source dataset

uspto-grants-2014_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08907118B2