反应详情

温度

32.5 °C

4-methylmorpholine (7.3 ml) followed by isobutylchloroformate (12.35 ml) was added to a suspension of (R)-2-acetamido-3-hydroxypropanoic acid (7 grams) in tetrahydrofuran (147 ml) at −78 to −75° C., benzylamine (10.4 ml) was added to it and the reaction mixture temperature was raised to 30-35° C. then stirred for 30 minutes. The reaction mixture was filtered and the filtrate was distilled off under reduced pressure. The obtained residue was dissolved in methylene chloride (35 ml) and washed with aqueous hydrochloric acid followed by sodium carbonate and then with water. The solvent from the methylene chloride layer was distilled off completely under reduced pressure to get the title compound.

1. filtrationThe reaction mixture was filtered
2. distillationthe filtrate was distilled off under reduced pressure
3. dissolutionThe obtained residue was dissolved in methylene chloride (35 ml)
4. washwashed with aqueous hydrochloric acid
5. distillationThe solvent from the methylene chloride layer was distilled off completely under reduced pressure