Lithium Hydroxide → HCID 66739710, compound

HRID 1402750Notes

Reaction equation

HRID 1402750 reaction equation
[OH:1][C:2]([C:5]1[N:10]=[CH:9][C:8]([C:11]([O:13]C)=[O:12])=[CH:7][CH:6]=1)([CH3:4])[CH3:3].[Li+:15].[OH-]>C1COCC1>[OH:1][C:2]([C:5]1[N:10]=[CH:9][C:8]([C:11]([O-:13])=[O:12])=[CH:7][CH:6]=1)([CH3:3])[CH3:4].[Li+:15]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 66739390HCID 66739390, compound

Product 1

HCID 66739710HCID 66739710, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a stirred solution of methyl 6-(1-hydroxy-1-methylethyl)pyridine-3-carboxylate (479 mg, 2.45 mmol) in THF, (10 mL) was added LiOH (2M aqueous solution, 1.35 mL, 2.70 mmol). After 4 hours the solvent was removed at reduced pressure to give the title compound (458 mg, 100%) that was used without further purification.

Workup

  1. customAfter 4 hours the solvent was removed at reduced pressure

Sources & evidence

ORD record
ord-73eb9239b930413fa618af73ae1a45f1
Source dataset
uspto-grants-2014_12
Patent number
US08912176B2

Reaction notes

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