Dimethylformamide → HCID 1266787, compound

HRID 1404434Notes

Reaction equation

[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].Br[CH2:8][CH2:9][C:10]1C=[CH:14][CH:13]=[CH:12][CH:11]=1.[H-].[Na+].C[N:19](C)C=O>>[N:19]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:9][CH2:8][N:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6]

Participants

Reactant 4

HCID 6228Dimethylformamide

HCID 7666Phenethyl bromide

HCID 120252-Pyrrolidone

HCID 24758Sodium hydride

Product 1

HCID 1266787HCID 1266787, compound

Procedure

1-(2-(Pyridin-2-yl)ethyl)pyrrolidin-2-one is prepared from 2-pyrrolidone and 2-bromo-ethylbenzene in N,N-dimethylformamide in the presence of sodium hydride (according to M. Matsukawa et al., NeuroToxicology 2004, 25, 293-302).

Sources & evidence

ORD record: ord-86a955769c3341a29d37ace735ba5b8a
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08912329B2

Reaction notes

Loading…