Hydrochloric Acid → HCID 86701838, compound

HRID 1406023Notes

Reaction equation

HRID 1406023 reaction equation
C(OC(=O)[NH:7][CH2:8][C@@H:9]([NH:16][C:17]([C:19]1[C:23]2[CH2:24][CH2:25][CH2:26][C:27]3[C:28](=[N:29][C:30]([NH:33][C:34]4[CH:39]=[CH:38][C:37]([C:40](=[O:49])[NH:41][CH:42]5[CH2:47][CH2:46][N:45]([CH3:48])[CH2:44][CH2:43]5)=[CH:36][C:35]=4[O:50][CH3:51])=[N:31][CH:32]=3)[C:22]=2[N:21]([CH3:52])[N:20]=1)=[O:18])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(C)(C)C.[ClH:54]>CO.C1COCC1.O1CCOCC1>[ClH:54].[ClH:54].[NH2:7][CH2:8][C@@H:9]([NH:16][C:17]([C:19]1[C:23]2[CH2:24][CH2:25][CH2:26][C:27]3[C:28](=[N:29][C:30]([NH:33][C:34]4[CH:39]=[CH:38][C:37]([C:40](=[O:49])[NH:41][CH:42]5[CH2:47][CH2:46][N:45]([CH3:48])[CH2:44][CH2:43]5)=[CH:36][C:35]=4[O:50][CH3:51])=[N:31][CH:32]=3)[C:22]=2[N:21]([CH3:52])[N:20]=1)=[O:18])[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 68358225HCID 68358225, compound

Product 1

HCID 86701838HCID 86701838, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of tert-butyl[(2S)-2-({[9-({2-methoxy-4-[(1-methylpiperidin-4-yl)carbamoyl]phenyl}amino)-1-methyl-1,4,5,6-tetrahydropyrazolo[4′,3′:6,7]cyclohepta[1,2-d]pyrimidin-3-yl]carbonyl}amino)-2-phenylethyl]carbamate (0.010 g, 0.014 mmol) in MeOH (0.2 mL) and THF (0.5 mL), 4M HCl in dioxane (0.2 mL) was added. The mixture was stirred at room temperature for 4 h. The organic solvent was evaporated to dryness to give the title compound in quantitative yield.

Workup

  1. customThe organic solvent was evaporated to dryness

Sources & evidence

ORD record
ord-f4b93adecfc84bb5a27320f3d308d5a1
Source dataset
uspto-grants-2014_12
Patent number
US08916577B2

Reaction notes

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