2-Chlorophenol → HCID 66790269, compound

HRID 1406347Notes

Reaction equation

HRID 1406347 reaction equation
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7](F)=[CH:6][C:5]=1[F:11])=[O:3].C([O-])([O-])=O.[K+].[K+].[Cl:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[OH:25]>CS(C)=O>[Cl:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[O:25][C:7]1[CH:8]=[CH:9][C:4]([C:2](=[O:3])[CH3:1])=[C:5]([F:11])[CH:6]=1

Participants

5

Reactant 3

HCID 72452-ChlorophenolHCID 11430Potassium CarbonateHCID 677702,4-Difluoroacetophenone

Product 1

HCID 66790269HCID 66790269, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent2×

Procedure

156 mg (1 mmol) of 2,4-difluoracetophenone were dissolved in 5 ml DMSO, taken and combined with 200 mg (1.45 mmol) of K2CO3. 128 mg (1 mmol) of 2-chlorophenol were dissolved in 5 ml DMSO and added thereto and the mixture was stirred for 2 days at ambient temperature. The reaction mixture was filtered through basic Alox, washed with DMF and concentrated by rotary evaporation. The substance was purified by reversed-phase chromatography.

Workup

  1. additionadded
  2. filtrationThe reaction mixture was filtered through basic Alox
  3. washwashed with DMF
  4. concentrationconcentrated by rotary evaporation
  5. customThe substance was purified by reversed-phase chromatography

Sources & evidence

ORD record
ord-feb0e147284f4378a566819d1a4393d4
Source dataset
uspto-grants-2014_12
Patent number
US08916589B2

Reaction notes

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