2-Methoxyethylamine → HCID 16003602, compound

HRID 1406488Notes

Reaction equation

HRID 1406488 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][NH2:5].[CH2:6]([O:8][C:9](=[O:20])[C:10]1[CH:15]=[CH:14][C:13](F)=[C:12]([N+:17]([O-:19])=[O:18])[CH:11]=1)[CH3:7].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[CH2:6]([O:8][C:9](=[O:20])[C:10]1[CH:15]=[CH:14][C:13]([NH:5][CH2:4][CH2:3][O:2][CH3:1])=[C:12]([N+:17]([O-:19])=[O:18])[CH:11]=1)[CH3:7]

Participants

5

Reactant 3

HCID 80182-MethoxyethylamineHCID 11430Potassium CarbonateHCID 21277355Ethyl 4-fluoro-3-nitrobenzoate

Product 1

HCID 16003602HCID 16003602, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2-Methoxy-ethylamine (1.55 mL, 17.8 mmol) was added to a stirred solution of 4-fluoro-3-nitro-benzoic acid ethyl ester (3.60 g, 16.9 mmol) and K2CO3 (4.67 g, 33.8 mmol) in 50 mL DMF. After stirring for 4 h the mixture was poured onto ice water, stirred for 10 min, filtered and dried.

Workup

  1. additionwas poured onto ice water
  2. stirringstirred for 10 min
  3. filtrationfiltered
  4. customdried

Sources & evidence

ORD record
ord-d82d418859f04b82b3f7f01c6df3b769
Source dataset
uspto-grants-2014_12
Patent number
US08916599B2

Reaction notes

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